The Chronic Renal Insufficiency Cohort Study targets risk factors for progression of chronic kidney disease and cardiovascular disease to provide researchers with new ways of understanding CKD.

The CRIC study provides unique and valuable knowledge about chronic kidney disease

The CRIC Study was established in 2001 by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) to improve the understanding of chronic kidney disease (CKD) and related cardiovascular illness. The study’s goals are:
  • To examine risk factors for progression of CKD and cardiovascular disease,
  • To develop models that identify high-risk subgroups,
  • To assist in the development of treatment trials and therapies.
The CRIC Study initially enrolled over 3900 people with CKD who remain in long-term follow-up. Beginning in 2013, an additional 1500 people with CKD are being invited to join the study with an emphasis on older Americans. The focus of the study has been expanded to include early forms of CKD and the broad impact of CKD on health status.

CRIC Scientific Discoveries

FGF23 elevation has been linked to greater risks of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD), but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with prevalent and incident LVH among CRIC Study participants.
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CRIC Collaborations

The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples.
Learn more about collaborating with CRIC >>
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