The CRIC Study was established to improve the understanding of chronic kidney disease and related cardiovascular illness and provides new insight about chronic kidney disease.


The CRIC Study is a major national research effort poised to make fundamental insights into the epidemiology, management, and outcomes of chronic kidney disease (CKD). The CRIC Study represents the largest, nationally representative prospective cohort of adults with chronic kidney disease with intended long-term follow up.

The CRIC Research Network (CRIC–RN) began the design of the study in 2001. During this first phase that ended in mid-2008, the CRIC-RN successfully recruited and characterized a cohort of nearly 4,000 individuals with chronic kidney disease. The second phase of the CRIC study, which began in 2008 and was completed in 2013, allowed for extended follow-up of study participants. The third phase of the study, which began in 2013 and ended recruitment in 2015, enrolled older Americans with less severe CKD, and extends follow-up of Phase 1 and 2 participants for an additional 5 years.

The CRIC-RN is a potent public asset promoting the health of populations with chronic kidney disease and is evolving further during CRIC’s third phase through outstanding opportunities:

  • To enhance scientific discovery through extended follow-up of the CRIC cohort and expansion of the study population to address key knowledge gaps
  • To leverage fully the CRIC-RN into a broad-based resource for the scientific community

CRIC Scientific Discoveries

FGF23 elevation has been linked to greater risks of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD), but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with prevalent and incident LVH among CRIC Study participants.
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CRIC Collaborations

The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples.
Learn more about collaborating with CRIC >>
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