The CRIC Study was established to improve the understanding of chronic kidney disease and related cardiovascular illness and provides new insight about chronic kidney disease.


The CRIC Research Network (CRIC–RN) began the design of the study in 2001. During this first phase that ended in mid-2008, the CRIC-RN successfully recruited and characterized a cohort of nearly 4,000 individuals with chronic kidney disease. The second phase of the CRIC study, which began in 2008 and was completed in 2013, allowed for extended follow-up of study participants. The third phase of the study, which began in 2013 and ended recruitment in 2015, enrolled over 1500 Americans with less severe CKD, and extended follow-up of Phase 1 and 2 participants for an additional 5 years.

In its next phase which will begin in 2018, the CRIC Study will continue its examination of the effect of a broad range of risk factors (from molecular biomarkers of disease pathways to clinical, demographic, and behavioral characteristics) on the progression of CKD and other health consequences, and will, in addition, develop and carry out novel approaches to deep phenotyping in CKD made possible by the use of cutting-edge remote data capture technologies.

The CRIC-RN is a potent public asset promoting the health of populations with chronic kidney disease and is evolving further during CRIC’s third phase through outstanding opportunities:

  • To enhance scientific discovery through extended follow-up of the CRIC cohort and expansion of the study population to address key knowledge gaps
  • To leverage fully the CRIC-RN into a broad-based resource for the scientific community

Funding for the CRIC Study was obtained under a cooperative agreement from National Institute of Diabetes and Digestive and Kidney Diseases (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, U01DK060902, U24DK060990, R01DK072231 and R01DK119199). In addition, this work is supported in part by Institutional awards, R01s and K awards.

CRIC Scientific Discoveries

FGF23 elevation has been linked to greater risks of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD), but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with prevalent and incident LVH among CRIC Study participants.
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CRIC Collaborations

The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples.
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